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Article

Retinitis Pigmentosa (Non-syndromic).

Advances in experimental medicine and biology - 1 Jan 2025

Hondur Ahmet, Tsang Stephen, Sharma Tarun, Diaconita Vlad

Abstract excerpt

The PDE complex has one α, one β, and two γ subunits. Mutations in each subunit can lead to AR-RP. The complex encodes a protein that play an important role in rod phototransduction and maintenance of the intracellular cGMP level by activating cGMP in response to photons. This closes the cGMP-gated ion channels and hyperpolarizes the photoreceptor cells to transduce the signal. PDE6G might be associated with...

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Share to Cyclic GMP
Share to Cyclic Nucleotide Phosphodiesterases, Type 6
Share to AR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Retinal Rod Photoreceptor Cells

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Source

Identifiers

PMID: 40736827
DOI: 10.1007/978-3-031-72230-1_25

Genes

AR
PDE6G

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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