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Article

Discovery of imidazo[1,2-b]pyridazine derivatives as potent TRK inhibitors for overcoming multiple resistant mutants.

Bioorganic chemistry - 1 Aug 2025

Xu Yunsheng, Zhao Wei, Wang Zhenghai, Chen Yinbo, Jia Zhongtian, Chu Yong, Zhu Xueyan, Zhang Peng

Abstract excerpt

Tropomyosin receptor kinases (TRKs), the superfamily of transmembrane receptor tyrosine kinases, have recently attracted extensive attention as promising cancer therapeutic targets since the approval of Larotrectinib, Entrectinib and Repotrectinib by FDA. Herein, we reported the discovery of a series of novel imidazo[1,2-b]pyridazine derivatives as potent second-generation TRK inhibitors. The representative...

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Source

Identifiers

PMID: 40669439
DOI: 10.1016/j.bioorg.2025.108737

Genes

F3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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