Multidimensional biocircuitry of exercise adaptation: integrating in vivo and ex vivo phenomics with miRNA mapping.

doi:10.1152/physiolgenomics.00068.2025

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Article

Multidimensional biocircuitry of exercise adaptation: integrating in vivo and ex vivo phenomics with miRNA mapping.

Physiological genomics - 1 Sept 2025

McAdam Jeremy S, Craig Michael P, Graham Zachary A, Peoples Brandon, Tuggle S Craig, Seay Regina S, Lavin Kaleen M, Gargus Amber B, O'Bryan Samia M, Yang Sufen, Drummer Devin J, Kelley Christian J, Peri Kalyani, Bell Margaret B, Aban Inmaculada, Cutter Gary R, Mahyari Arash, Wen Yuan, Zhang Jin, Hira Akshay, Broderick Timothy J, Kadakia Madhavi P, Bamman Marcas M

Abstract excerpt

In a randomized, dose-response trial, we used molecular and phenomic profiling to compare responses with traditional moderate-intensity endurance and resistance training (TRAD) versus high-intensity tactical training (HITT) that encompassed explosive whole-body interval training and high-intensity resistance training. Ninety-four participants (18-27 yr) completed 12 wk of TRAD or HITT followed by 4 wk of...

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PMID: 40658616
DOI: 10.1152/physiolgenomics.00068.2025

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