The Role of Mitochondrial Dysfunction and Oxidative Stress in Women’s Reproductive Disorders: Implications for Polycystic Ovary Syndrome and Preeclampsia

Abstract excerpt

Despite decades of research, the pathophysiology of preeclampsia (PE) and polycystic ovary syndrome (PCOS) remains poorly understood. Notably, no new FDA-approved treatments for PE have emerged in over 50 years. PCOS, a common endocrine disorder, increases a woman's risk of developing PE. Both conditions share overlapping mechanisms, including insulin resistance, chronic inflammation, endothelial dysfunction, and...

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