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Article

Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics

11 Jul 2025

Abstract excerpt

Filarial nematodes, responsible for diseases like lymphatic filariasis and onchocerciasis, depend on symbiotic Wolbachia bacteria for reproduction and development. Using the Litomosoides sigmodontis rodent model, we investigated how host type-2 immunity influences Wolbachia dynamics and parasite development. Wild-type and type-2 immune-deficient (Il4rα⁻/⁻Il5⁻/⁻) BALB/c mice were infected with L. sigmodontis, and...

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PMID: 40644522
DOI: 10.1371/journal.ppat.1013301

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