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Article

TEK-related venous malformation of the orofacial region: report of a case with multidisciplinary treatment guided by molecular diagnosis.

Oral surgery, oral medicine, oral pathology and oral radiology - 1 Nov 2025

Cheng Yi-Shing Lisa, Bustamante Daniel, Yates David M, Menendez Silvia, Chi Angela C

Abstract excerpt

Vascular malformations (VMs) often affect the orofacial region, where they can markedly impact the quality of life. They frequently harbor mutations in TEK, PIK3CA, or other genes essential for angiogenesis. Alpelisib is a phosphatidylinositol 3-kinase inhibitor recently shown to be effective for treating VMs with PIK3CA or TEK mutations. Herein we describe a 13-year-old female with an orofacial VM present since...

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Identifiers

PMID: 40603171
DOI: 10.1016/j.oooo.2025.05.009

Genes

TEK
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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