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Article

Impact of Lacosamide, Silver Nanoparticles, and Their PEG-Conjugates on Life History Traits and Behavioral Responses in parabss1 Mutant Drosophila.

Journal of applied toxicology : JAT - 1 Oct 2025

Abbigeri Megha B, Thokchom Bothe, Singh Sapam Riches, Kulkarni Sudheendra Rao, Bhavi Santosh Mallikarjun, Yarajarla Ramesh Babu

Abstract excerpt

The present study investigates the effects of lacosamide (LCM), silver nanoparticles (AgNPs), and their polyethylene glycol (PEG)-based conjugates on parabss1 mutant Drosophila melanogaster, a model for epilepsy. Flies were cultured on standard wheat cream agar medium at 22± 1°C and exposed to three concentrations (2.5, 5, and 10 μg/mL) of each treatment. The size of the AgNPs was noted to be 8.21 ± 0.40 nm. Key...

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PMID: 40545338
DOI: 10.1002/jat.4835

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