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Article

Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1

1 Jun 2025

Abstract excerpt

Vault RNAs (vtRNAs) are a family of four small non-coding RNAs that regulate multiple cellular pathways in human cells. VtRNA expression is increased upon infection with certain RNA and DNA viruses, suggesting that they either promote or restrict viral replication. However, their precise molecular function remains unclear. We show that replication of picornaviruses, alphaviruses, and beta-coronaviruses broadly...

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PMID: 40512618
DOI: 10.1016/j.celrep.2025.115823

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