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Article

Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology.

Nature cancer - 1 Aug 2025

Ferber Dyke, El Nahhas Omar S M, Wölflein Georg, Wiest Isabella C, Clusmann Jan, Leßmann Marie-Elisabeth, Foersch Sebastian, Lammert Jacqueline, Tschochohei Maximilian, Jäger Dirk, Salto-Tellez Manuel, Schultz Nikolaus, Truhn Daniel, Kather Jakob Nikolas

Abstract excerpt

Clinical decision-making in oncology is complex, requiring the integration of multimodal data and multidomain expertise. We developed and evaluated an autonomous clinical artificial intelligence (AI) agent leveraging GPT-4 with multimodal precision oncology tools to support personalized clinical decision-making. The system incorporates vision transformers for detecting microsatellite instability and KRAS and BRAF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 40481323
DOI: 10.1038/s43018-025-00991-6
PMCID: PMC12380607

Genes

GPT
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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