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CagA-dependent Hobit + gastric tissue-resident memory T cells confer full protection from Helicobacter pylori reinfection

5 Jun 2025

Abstract excerpt

Background Helicobacter pylori infection is the most prevalent bacterial infection worldwide. Attempts to develop a vaccine have not been successful, partly due to the absence of well-defined immune correlates of protection. The inflammatory response to H. pylori infection is characterised by the recruitment of T cells expressing markers of tissue-resident memory T (T RM ) cells to the gastric mucosa. However,...

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PMID: 40473399
DOI: 10.1136/gutjnl-2025-334781

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