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A resource for whole-body gene expression map of human tissues based on integration of single cell and bulk transcriptomics

3 Jun 2025

Abstract excerpt

New technologies enable single-cell transcriptome analysis, mapping genome-wide expression across the human body. Here, we present an extended analysis of protein-coding genes in all major human tissues and organs, combining single-cell and bulk transcriptomics. To enhance transcriptome depth, 31 tissues were analyzed using a pooling method, identifying 557 unique cell clusters, manually annotated by marker gene...

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PMID: 40462185
DOI: 10.1186/s13059-025-03616-4

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