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Article

YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis

30 May 2025

Abstract excerpt

BACKGROUND: As a member of the family of the YTH domain and a an m6A reader, YTHDF3 is implicated in cancer and inflammatory diseases. However, its function in ankylosing spondylitis (AS)-a chronic inflammatory disease marked by aberrant bone formation-is still mysterious. The research set out to study how YTHDF3 may promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in AS and...

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PMID: 40448194
DOI: 10.1186/s12967-025-06607-y

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