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Implementation and clinical utility of multigene panels for bleeding, platelet, and thrombotic disorders.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2025

Ramanan Radha, Verstraete Andreas, Van Laer Christine, Freson Kathleen

Abstract excerpt

High-throughput sequencing, with its capacity to simultaneously sequence large volumes of genomic data, has evolved from a research-focused technology to a clinical tool. This review outlines key steps in the development of a clinical hemostasis and thrombosis genetics service leveraging a multigene panel. We discuss its value across inherited bleeding, platelet, and thrombotic disorders (BPTDs) in the context of...

Topics

Humans
Thrombosis
Genetic Predisposition to Disease
Genetic Testing
High-Throughput Nucleotide Sequencing
Blood Platelet Disorders
Phenotype
Predictive Value of Tests
Hemorrhage
Hemostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Blood Coagulation

Genetic Variation

Mutation

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Open in PubMed Open full text

Identifiers

PMID: 40345666
DOI: 10.1016/j.jtha.2025.04.026
PMCID: PMC12212629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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