Detection of the mecA Gene and Its Association With Antimicrobial Resistance Among Coagulase-Negative Staphylococci Isolated From Clinical Samples in a Tertiary Care Hospital: A Cross-Sectional Study

Abstract excerpt

Introduction Coagulase-Negative Staphylococci (CoNS) have become major pathogens causing a variety of infections. Antimicrobial resistance, brought about by the acquisition of the mecA gene, further exacerbates this burden. This gene encodes the altered membrane-bound protein called penicillin-binding protein (PBP2a), which lowers the binding affinity for β-lactam antibiotics. The widespread distribution of this...

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