Comparative Efficacy of Swim-Up, Density-Gradient Centrifugation, and Microfluidic Sorting in Sperm Preparation, and the Impact on Motility, Morphology, and DNA Integrity

Abstract excerpt

Background: Reactive oxygen species (ROS) are considered a major factor contributing to sperm DNA damage during sperm preparation for assisted reproductive technologies (ART). This study aimed to investigate whether microfluidic sorting can select sperm with a low DNA fragmentation index (DFI) and to explore the underlying mechanisms. We compared the effects of three sperm preparation methods—swim-up,...

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