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Napsin A as a key prognostic biomarker in spinal metastases of lung cancer: implications for survival and neurological function.

Neurosurgical focus - 1 May 2025

Antar Albert, Al-Mistarehi Abdel-Hameed, Davidar A Daniel, Xia Yuanxuan, Papali Pritika, Sriram Shreya, Alfonzo Horowitz Melanie, Sattari Shahab Aldin, Neerumalla Sushanth, Weber-Levine Carly, Lee Sang Hun, Redmond Kristin J, Bydon Ali, Witham Timothy F, Theodore Nicholas, Bilsky Mark H, Lubelski Daniel

Abstract excerpt

OBJECTIVE: Lung cancer's propensity for metastasizing to the spine significantly impacts morbidity and mortality. Understanding the impact of somatic mutations on the prognosis of these metastases is crucial for treatment development and optimization. METHODS: A retrospective analysis was performed on a neurosurgical cohort of 76 patients with lung cancer with spinal metastasis (LCSM) at a single comprehensive...

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Identifiers

PMID: 40311196
DOI: 10.3171/2025.2.FOCUS24897

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EGFR
KRAS

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