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Taurine is a potential therapy for rheumatoid arthritis via targeting FOXO3 through cellular senescence and autophagy

16 Apr 2025

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease closely related to aging with unclear pathogenic mechanisms. This study aims to identify the biomarkers in RA, aging and autophagy using bioinformatics and machine learning and explore the binding stability of taurine to target utilizing computer-aided drug design (CADD). METHODS: We identified differentially expressed genes (DEGs)...

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PMID: 40238799
DOI: 10.1371/journal.pone.0318311

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