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Lake Malawi cichlid pangenome graph reveals extensive structural variation driven by transposable elements.

Genome research - 2 May 2025

Quah Fu Xiang, Almeida Miguel Vasconcelos, Blumer Moritz, Yuan Chengwei Ulrika, Fischer Bettina, See Kirsten, Jackson Ben, Zatha Richard, Rusuwa Bosco, Turner George F, Santos M Emília, Svardal Hannes, Hemberg Martin, Durbin Richard, Miska Eric

Abstract excerpt

Pangenome methods have the potential to uncover hitherto undiscovered sequences missing from established reference genomes, making them useful to study evolutionary and speciation processes in diverse organisms. The cichlid fishes of the East African Rift Lakes represent one of nature's most phenotypically diverse vertebrate radiations, but single-nucleotide polymorphism (SNP)-based studies have revealed little...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40210437
DOI: 10.1101/gr.279674.124
PMCID: PMC12047535

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