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Article

Why some and not others? Understanding vascular phenotypes in genetic developmental lung diseases.

Current opinion in pediatrics - 1 Jun 2025

Steffes Lea C, Kumar Maya E, Varghese Nidhy P

Abstract excerpt

PURPOSE OF REVIEW: Pulmonary vascular disease is more common in certain genetic developmental lung disorders. This review synthesizes clinical descriptions, molecular analyses, and single-cell transcriptional data to build a conceptual framework to help understand why some variants affect the vasculature while others primarily manifest with parenchymal disease. RECENT FINDINGS: Genes predominantly expressed in...

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Identifiers

PMID: 40172258
DOI: 10.1097/MOP.0000000000001459
PMCID: PMC12113387

Genes

ABCA3
FGF10
FOXF1
KDR
SFTPC
TBX4

Provenance

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