Article
Computational drug repurposing: approaches, evaluation of in silico resources and case studies.
Nature reviews. Drug discovery - 1 Jul 2025
Tanoli Ziaurrehman, Fernández-Torras Adrià, Özcan Umut Onur, Kushnir Aleksandr, Nader Kristen Michelle, Gadiya Yojana, Fiorenza Laura, Ianevski Aleksandr, Vähä-Koskela Markus, Miihkinen Mitro, Seemab Umair, Leinonen Henri, Seashore-Ludlow Brinton, Tampere Marianna, Kalman Adelinn, Ballante Flavio, Benfenati Emilio, Saunders Gary, Potdar Swapnil, Gómez García Ismael, García-Serna Ricard, Talarico Carmine, Beccari Andrea Rosario, Schaal Wesley, Polo Andrea, Costantini Susan, Cabri Enrico, Jacobs Marc, Saarela Jani, Budillon Alfredo, Spjuth Ola, Östling Päivi, Xhaard Henri, Quintana Jordi, Mestres Jordi, Gribbon Philip, Ussi Anton E, Lo Donald C, de Kort Martin, Wennerberg Krister, Fratelli Maddalena, Carreras-Puigvert Jordi, Aittokallio Tero
Abstract excerpt
Repurposing of existing drugs for new indications has attracted substantial attention owing to its potential to accelerate drug development and reduce costs. Hundreds of computational resources such as databases and predictive platforms have been developed that can be applied for drug repurposing, making it challenging to select the right resource for a specific drug repurposing project. With the aim of helping...
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