Human scalp hair follicles can ‘taste’: chemosensory signalling via the bitter taste receptor TAS2R4 inhibits hair growth ex vivo

Abstract excerpt

BACKGROUND: Taste receptors (TRs) exert many 'nongustatory' chemosensory functions beyond the sensation of taste. Recently, human keratinocytes have been found to express some bitter TRs, whose physiological functions remain unknown. As it has been discovered that human scalp hair follicles (HFs) use olfactory receptors to regulate their growth, we hypothesized that some bitter TRs may exert a similar function....

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