A biogeographical ancestry inference pipeline using PCA-XGBoost model and its application in Asian populations.

Abstract excerpt

Biogeographical ancestry (BGA) inference plays a crucial role in genetics, anthropology, forensic science, and medical research. Current methods like principal component analysis (PCA) and ADMIXTURE, based on single nucleotide polymorphisms, are commonly used. Here, we introduce a bio-geographical ancestry inference pipeline that integrates prior population structure and clustering. Our pipeline first analyzes...

Topics

• Humans
• Principal Component Analysis
• Genetics, Population
• Asian People
• Polymorphism, Single Nucleotide
• Likelihood Functions