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Predicted Risk of Ventricular Arrhythmias in a Genome-First Population With Genetic Risk for Arrhythmogenic Right Ventricular Cardiomyopathy.

Circulation. Arrhythmia and electrophysiology - 1 Mar 2025

Carruth Eric D, Murray Brittney, Tichnell Crystal, Young Katelyn, Calkins Hugh, James Cynthia A, Haggerty Christopher M

Abstract excerpt

BACKGROUND: Population genomic screening for desmosome variants associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) may facilitate early disease detection and protective intervention. The validated ARVC risk calculator offers a novel means to risk stratify individuals with diagnosed ARVC, but predicted risk in the context of genomic screening identification has not been explored. METHODS:...

Topics

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Arrhythmogenic Right Ventricular Dysplasia
Desmoglein 2
Desmoplakins
Desmosomes
Plakophilins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Risk Assessment

Tachycardia, Ventricular

Source

Open in PubMed Open full text

Identifiers

PMID: 39989366
DOI: 10.1161/CIRCEP.124.013231
PMCID: PMC12107468

Genes

DSP
PKP2
DSC2
DSG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Predicted Risk of Ventricular Arrhythmias in a Genome-First Population With Genetic Risk for Arrhythmogenic Right Ventricular Cardiomyopathy.PMID 39989366Read ↗

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