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Comparative transcriptomics reveals different profiles between diflubenzuron-resistant and -susceptible phenotypes of the mosquito Culex pipiens.

Pest management science - 1 Jun 2025

Valentina Mastrantonio, Franco Liberati, Tiziana Castrignanò, Valentina Lucchesi, Sandra Urbanelli, Romeo Bellini, John Vontas, Daniele Porretta

Abstract excerpt

BACKGROUND: Chitin-synthesis inhibitors (CSIs) represent a major tool in vector control. The intensive use of these compounds has led to the evolution of resistance against several CSIs, including diflubenzuron (DFB). DFB resistance has been associated to a target-site mechanism; however, studies investigating the gene expression profile of resistant phenotypes are limited, preventing a full understanding of DFB...

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PMID: 39943702
DOI: 10.1002/ps.8710
PMCID: PMC12074624

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