The Immunogenicity of Coxsackievirus A6 (D3a Sub-Genotype) Virus-Like Particle and mRNA Vaccines.

doi:10.1002/jmv.70201

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Article

The Immunogenicity of Coxsackievirus A6 (D3a Sub-Genotype) Virus-Like Particle and mRNA Vaccines.

Journal of medical virology - 1 Feb 2025

Lu Huanhuan, Xiao Jinbo, Song Jingdong, Song Yang, Li Hai, Ren Hu, Li Jichen, Cong Ruyi, Li Hangwen, Fang Yi, Yan Dongmei, Zhu Shuangli, Sun Qiang, Liu Ying, Zhang Yong

Abstract excerpt

In recent years, coxsackievirus A6 (CVA6) has surpassed enterovirus A71 to become the main pathogen causing severe Hand, Foot, and Mouth disease (HFMD) in China with a substantial disease burden. However, there is currently no commercial CVA6 vaccine. The D3a genotype of CVA6 is the predominant genotype in China. In this study, virus-like particles (VLPs) and mRNA vaccines based on the CVA6 sub-genotype D3a were...

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Topics

Animals
Antibodies, Neutralizing
Vaccines, Virus-Like Particle
Antibodies, Viral
Mice
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Enterovirus A, Human

Mice, Inbred ICR

mRNA Vaccines

Immunogenicity, Vaccine

Viral Vaccines

Adjuvants, Immunologic

Genotype

Vaccines, Synthetic

China

Hand, Foot and Mouth Disease

Disease Models, Animal

Adjuvants, Vaccine

Source

Open in PubMed

Identifiers

PMID: 39921385
DOI: 10.1002/jmv.70201

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