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Metagenome-guided culturomics for the targeted enrichment of gut microbes

14 Jan 2025

Abstract excerpt

The gut microbiome significantly impacts human health, yet cultivation challenges hinder its exploration. Here, we combine deep whole-metagenome sequencing with culturomics to selectively enrich for taxa and functional capabilities of interest. Using a modified commercial base medium, 50 growth modifications were evaluated, spanning antibiotics, physico-chemical conditions, and bioactive compounds....

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Diet and metabolism studies
Gut microbiota and health
Probiotics and Fermented Foods

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39809763
DOI: 10.1038/s41467-024-55668-y

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