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Life stage impact on the human skin ecosystem: lipids and the microbial community

12 Jan 2025

Abstract excerpt

Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between skin oxylipins and microbes on the superficial skin of pre-pubescent children (N = 36) and adults (N = 100), including pre- (N = 25) and post-menopausal females (N = 25). Lipidomics and metagenomics revealed that Malassezia restricta positively...

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PMID: 39800795
DOI: 10.1038/s41522-025-00652-7

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