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Article

Insights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation.

International journal of molecular sciences - 17 Dec 2024

Abdelbary Mohamed M H, Hatting Maximilian, Dahlhausen Andrea, Bott Alexandra, Conrads Georg

Abstract excerpt

The oral-gut axis is a complex system linking the oral cavity and gastrointestinal tract, impacting host health and microbial composition. This study investigates genetic changes and adaptive mechanisms employed by streptococci-one of the few genera capable of colonizing oral and intestinal niches-within the same individual. We conducted whole-genome sequencing (WGS) on 218 streptococcal isolates from saliva and...

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PMID: 39769268
DOI: 10.3390/ijms252413507

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