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Article

Novel allelic variants of blaOXA-48-like carried on IncN2 and IncC2 plasmids isolated from clinical cases in Argentina: In vivo emergence of blaOXA-567.

Journal of global antimicrobial resistance - 1 Mar 2025

de Mendieta Juan Manuel, De Belder Denise, Tijet Nathalie, Ghiglione Barbara, Melano Roberto G, Rapoport Melina, Power Pablo, Di Bella Adriana, Biondi Estefanía, Pasterán Fernando, Corso Alejandra, Gomez Sonia A

Abstract excerpt

OBJECTIVE: The OXA-48-like enzymes have the capacity to hydrolyse carbapenems and are members of class D β-lactamases that are primarily detected in Enterobacterales. The allelic variant blaOXA-163, which has low hydrolytic activity towards carbapenems, was detected in Argentina in 2011 and has spread successfully since then, giving sporadic origin to novel local variants. The aim of this study was to analyse the...

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PMID: 39725323
DOI: 10.1016/j.jgar.2024.12.008

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