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Autophagy promotes p72 degradation and capsid disassembly during the early phase of African swine fever virus infection

17 Dec 2024

Abstract excerpt

ABSTRACT During viral infections, autophagy functions as a cell-intrinsic defense mechanism by facilitating the delivery of virions or viral components to the endosomal/lysosomal pathway for degradation. In this study, we report that internalized African swine fever virus (ASFV) virions enter autolysosomes during the early phase of viral infection. Autophagy selectively targets the major capsid protein p72 within...

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PMID: 39688418
DOI: 10.1128/jvi.01701-24

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