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The Microbiota and Evolution of Obesity

13 Dec 2024

Abstract excerpt

Obesity is a major global concern and is generally attributed to a combination of genetic and environmental factors. Several hypotheses have been proposed to explain the evolutionary origins of obesity epidemic, including thrifty and drifty genotypes, and changes in thermogenesis. Here, we put forward the hypothesis of metaflammation, which proposes that due to intense selection pressures exerted by environmental...

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PMID: 39673174
DOI: 10.1210/endrev/bnae033

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