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Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer

27 Nov 2024

Abstract excerpt

BACKGROUND: Patients with microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapies. Nivolumab plus ipilimumab has shown clinical benefit in nonrandomized studies of MSI-H or dMMR metastatic colorectal cancer. METHODS: In this phase 3 open-label trial, we randomly assigned patients with...

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PMID: 39602630
DOI: 10.1056/nejmoa2402141

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