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Article

Mendelian randomization analysis reveals causal effects of inflammatory bowel disease and autoimmune hyperthyroidism on diffuse large B-cell lymphoma risk.

Scientific reports - 25 Nov 2024

Lyu Chunyi, Wang Yan, Xu Ruirong

Abstract excerpt

The clinical phenomenon whereby diffuse large B-cell lymphoma (DLBCL) occurs in patients with a history of autoimmune disease (AD) has been noted, but it remains controversial. This study aimed to evaluate the causal associations between nine ADs and DLBCL via a Mendelian randomization (MR) study. Single-nucleotide polymorphism (SNP) obtained from published genome-wide association studies (GWAS) was chosen as...

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Autoimmune Diseases
Case-Control Studies
Genome-Wide Association Study
Hyperthyroidism
Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Large B-Cell, Diffuse

Mendelian Randomization Analysis

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Identifiers

PMID: 39587169
DOI: 10.1038/s41598-024-79791-4
PMCID: PMC11589711

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