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Characterizing Escherichia coli carrying plasmid-mediated AmpC β-lactamases to optimize detection in a diagnostic laboratory setting.

Microbiology spectrum - 5 Dec 2024

Teng Jason, Walters Luke, Leong Lex E X, Smith Kija, Amato Malissa, Chen Xiao, Turra Mark, Warner Morgyn S, Papanicolas Lito E

Abstract excerpt

Plasmid-mediated AmpC β-lactamases are a cause of acquired cephalosporin resistance in Gram-negative bacteria. However, consensus regarding the optimal detection method is yet to be achieved and varies depending on local epidemiology and laboratory capacity. We determined the acquired genotypic resistance mechanisms of 250 Escherichia coli isolates with a positive AmpC screen, defined as cefoxitin MIC ≥ 8 mg/L...

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Anti-Bacterial Agents
beta-Lactamases
Cefoxitin
Escherichia coli
Escherichia coli Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Whole Genome Sequencing

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PMID: 39508642
DOI: 10.1128/spectrum.00933-24
PMCID: PMC11619294

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