Alterations of oral microbiome and metabolic signatures and their interaction in oral lichen planus

Abstract excerpt

Background Oral lichen planus (OLP) is a chronic oral mucosal inflammatory disease with a risk of becoming malignant. Emerging evidence suggests that microbial imbalance plays an important role in the development of OLP. However, the association between the oral microbiota and the metabolic features in OLP is still unclear.Methods We conducted 16S rRNA sequencing and metabolomics profiling on 95 OLP patients and...

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