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Article

Reconciling theories of dominance with the relative rates of adaptive substitution on sex chromosomes and autosomes.

Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 2024

McDonough Yasmine, Ruzicka Filip, Connallon Tim

Abstract excerpt

The dominance of beneficial mutations is a key evolutionary parameter affecting the rate and genetic basis of adaptation, yet it is notoriously difficult to estimate. A leading method to infer it is to compare the relative rates of adaptive substitution for X-linked and autosomal genes, which-according to a classic model by Charlesworth et al. (1987)-is a simple function of the dominance of new beneficial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39436652
DOI: 10.1073/pnas.2406335121
PMCID: PMC11536091

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