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Article

Innovative approaches in phenotypic beta-lactamase detection for personalised infection management.

Nature communications - 21 Oct 2024

Lawrence Jennifer, O'Hare Danny, van Batenburg-Sherwood Joseph, Sutton Mark, Holmes Alison, Rawson Timothy Miles

Abstract excerpt

Beta-lactamase-producing Enterobacteriaceae present a significant therapeutic challenge. Current developments in phenotypic diagnostics focus primarily on rapid minimum inhibitory concentration (MIC) determination. There is a requirement for rapid phenotypic diagnostics to improve antimicrobial susceptibility tests (AST) and aid prescribing decisions. Phenotypic AST are limited in their ability to characterise...

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Identifiers

PMID: 39433753
DOI: 10.1038/s41467-024-53192-7
PMCID: PMC11494114

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