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Article

Systemic Immune Factors and Risk of Allergic Contact Dermatitis: A Bidirectional Mendelian Randomization Study.

International journal of molecular sciences - 27 Sept 2024

Long Yingxin, Dai Wenzhang, Cai Kexin, Xiao Yuan, Luo Anqi, Lai Ziwei, Wang Junlin, Xu Lipeng, Nie Hong

Abstract excerpt

Skin inflammation and immune regulation have been suggested to be associated with allergic contact dermatitis (ACD) progression, but whether the system's immune regulation is a cause or a potential mechanism is still unknown. This study aims to assess the upstream and downstream of systemic immune factors on ACD within a bidirectional Mendelian-randomization design. A bidirectional two-sample MR analysis was...

Topics

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Complement C4
Dermatitis, Allergic Contact
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

TNF-Related Apoptosis-Inducing Ligand

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Identifiers

PMID: 39408763
DOI: 10.3390/ijms251910436
PMCID: PMC11476522

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