Article
Aberrant serum-derived FN1 variants bind to integrin β1 on glomerular endothelial cells contributing to thin basement membrane nephropathy.
International journal of biological macromolecules - 1 Nov 2024
Zhou Xindi, Chen Wanbing, Gan Chun, Chen Dan, Xiao Han, Jiang Yaru, Yang Qing, Jiang Huimin, Yang Xuejun, Yang Baohui, Chen Yaxi, Wang Mo, Yang Haiping, Jiang Wei, Li Qiu
Abstract excerpt
The glomerular basement membrane (GBM) is a critical component of the glomerular filtration barrier (GFB), with its thickness directly influencing renal function. While a uniformly thinned GBM can cause hematuria while preserving normal renal function, this condition is typically diagnosed as thin basement membrane nephropathy (TBMN). However, the pathogenesis and potential progression to renal insufficiency of...
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