Article
Potential Involvements of Cilia-Centrosomal Genes in Primary Congenital Glaucoma.
International journal of molecular sciences - 18 Sept 2024
Pyatla Goutham, Kabra Meha, Mandal Anil K, Zhang Wei, Mishra Ashish, Bera Samir, Rathi Sonika, Patnaik Satish, Anthony Alice A, Dixit Ritu, Banerjee Seema, Shekhar Konegari, Marmamula Srinivas, Kaur Inderjeet, Khanna Rohit C, Chakrabarti Subhabrata
Abstract excerpt
Primary congenital glaucoma (PCG) occurs in children due to developmental abnormalities in the trabecular meshwork and anterior chamber angle. Previous studies have implicated rare variants in CYP1B1, LTBP2, and TEK and their interactions with MYOC, FOXC1, and PRSS56 in the genetic complexity and clinical heterogeneity of PCG. Given that some of the gene-encoded proteins are localized in the centrosomes (MYOC)...
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