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Article

Navigating therapeutic challenges in VEXAS syndrome: exploring IL-6 and JAK inhibitors at the forefront.

Molecular medicine (Cambridge, Mass.) - 17 Sept 2024

Li Xiao Xiao, Huang Wen Hui, Yang Xiao Bin, Yang Qi Lin, Zheng Yu, Huo Yong Bao, Xie Ting Ting, Huang Cheng Hui, Yu Shui Lian

Abstract excerpt

VEXAS syndrome, an uncommon yet severe autoimmune disorder stemming from a mutation in the UBA1 gene, is the focus of this paper. The overview encompasses its discovery, epidemiological traits, genetic underpinnings, and clinical presentations. Delving into whether distinct genotypes yield varied clinical phenotypes in VEXAS patients, and the consequent adjustment of treatment strategies based on genotypic and...

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Identifiers

PMID: 39289602
DOI: 10.1186/s10020-024-00922-8
PMCID: PMC11409618

Genes

UBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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