Article
Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies.
Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2024
Laabs Björn-Hergen, Lohmann Katja, Vollstedt Eva-Juliane, Reinberger Tobias, Nuxoll Lisa-Marie, Kilic-Berkmen Gamze, Perlmutter Joel S, Loens Sebastian, Cruchaga Carlos, Franke Andre, Dobricic Valerija, Hinrichs Frauke, Grözinger Anne, Altenmüller Eckart, Bellows Steven, Boesch Sylvia, Bressman Susan B, Duque Kevin R, Espay Alberto J, Ferbert Andreas, Feuerstein Jeanne S, Frank Samuel, Gasser Thomas, Haslinger Bernhard, Jech Robert, Kaiser Frank, Kamm Christoph, Kollewe Katja, Kühn Andrea A, LeDoux Mark S, Lohmann Ebba, Mahajan Abhimanyu, Münchau Alexander, Multhaupt-Buell Trisha, Pantelyat Alexander, Pirio Richardson Sarah E, Raymond Deborah, Reich Stephen G, Saunders Pullman Rachel, Schormair Barbara, Sharma Nutan, Sichani Azadeh Hamzehei, Simonyan Kristina, Volkmann Jens, Wagle Shukla Aparna, Winkelmann Juliane, Wright Laura J, Zech Michael, Zeuner Kirsten E, Zittel Simone, Kasten Meike, Sun Yan V, Bäumer Tobias, Brüggemann Norbert, Ozelius Laurie J, Jinnah Hyder A, Klein Christine, König Inke R
Abstract excerpt
BACKGROUND: Despite considerable heritability, previous smaller genome-wide association studies (GWASs) have not identified any robust genetic risk factors for isolated dystonia. OBJECTIVE: The objective of this study was to perform a large-scale GWAS in a well-characterized, multicenter sample of >6000 individuals to identify genetic risk factors for isolated dystonia. METHODS: Array-based GWASs were performed...
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