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Exploiting branched-chain amino acid metabolism and NOTCH3 expression to predict and target colorectal cancer progression

2 Sept 2024

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Background The interplay between colon adenocarcinoma (COAD) and branched-chain amino acid (BCAA) metabolism is not fully understood, presenting a crucial area for investigation. Methods We developed a prognostic model based on BCAA metabolism using the least absolute shrinkage and selection operator (LASSO) regression algorithm. We employed qRT-PCR and Western blot analyses to examine NOTCH3 expression in COAD...

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PMID: 39286249
DOI: 10.3389/fimmu.2024.1430352

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