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Article

Apoptosis-Cell Cycle-Autophagy Molecular Mechanisms Network in Heterogeneous Aggressive Phenotype Prostate Hyperplasia Primary Cell Cultures Have a Prognostic Role.

International journal of molecular sciences - 28 Aug 2024

Matei Elena, Enciu Manuela, Roșu Mihai Cătălin, Voinea Felix, Mitroi Anca Florentina, Deacu Mariana, Băltățescu Gabriela Isabela, Nicolau Antonela-Anca, Chisoi Anca, Aşchie Mariana, Ionescu Mitu Anita Cristina

Abstract excerpt

Our study highlights the apoptosis, cell cycle, DNA ploidy, and autophagy molecular mechanisms network to identify prostate pathogenesis and its prognostic role. Caspase 3/7 expressions, cell cycle, adhesion glycoproteins, autophagy, nuclear shrinkage, and oxidative stress by flow-cytometry analysis are used to study the BPH microenvironment's heterogeneity. A high late apoptosis expression by caspases 3/7...

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Identifiers

PMID: 39273277
DOI: 10.3390/ijms25179329
PMCID: PMC11394677

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