Article
Human papillomavirus disease in GATA2 deficiency: a genetic predisposition to HPV-associated female anogenital malignancy.
Frontiers in immunology - 1 Jan 2024
Dancy Ehren, Stratton Pamela, Pichard Dominique C, Marciano Beatriz E, Cowen Edward W, McBride Alison A, Van Doorslaer Koenraad, Merideth Melissa A, Salmeri Noemi, Hughes Marybeth S, Heller Theo, Parta Mark, Hickstein Dennis D, Kong Heidi H, Holland Steven M, Zerbe Christa S
Abstract excerpt
Objective: Patients with pathogenic variants in the GATA Binding Protein 2 (GATA2), a hematopoietic transcription factor, are at risk for human papillomavirus-related (HPV) anogenital cancer at younger than expected ages. A female cohort with GATA2 haploinsufficiency was systematically assessed by two gynecologists to characterize the extent and severity of anogenital HPV disease, which was also compared with...
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