Article
Individuals carrying the HLA-B*15 allele exhibit favorable responses to COVID-19 vaccines but are more susceptible to Omicron BA.5.2 and XBB.1.16 infection.
Frontiers in immunology - 1 Jan 2024
Meng Lingxin, Pan Yue, Liu Yueping, He Rui, Sun Yuting, Wang Chenhui, Fei Lei, Zhu Airu, Wang Zhongfang, An Yunfei, Wu Yuzhang, Diao Bo, Chen Yongwen
Abstract excerpt
Background: Natural infection or vaccination have provided robust immune defense against SARS-CoV-2 invasion, nevertheless, Omicron variants still successfully cause breakthrough infection, and the underlying mechanisms are poorly understood. Methods: Sequential blood samples were continuously collected at different time points from 252 volunteers who were received the CanSino Ad5-nCoV (n= 183) vaccine or the...
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