Article
Molecular epidemiology and evolutionary characteristics of dengue virus 2 in East Africa.
Nature communications - 7 Sept 2024
Nyathi Sindiso, Rezende Izabela M, Walter Katharine S, Thongsripong Panpim, Mutuku Francis, Ndenga Bryson, Mbakaya Joel O, Aswani Peter, Musunzaji Peter S, Chebii Philip K, Maina Priscilla W, Mutuku Paul S, Ng'ang'a Charles M, Malumbo Said L, Jembe Zainab, Vu David M, Mordecai Erin A, Bennett Shannon, Andrews Jason R, LaBeaud A Desiree
Abstract excerpt
Despite the increasing burden of dengue, the regional emergence of the virus in Kenya has not been examined. This study investigates the genetic structure and regional spread of dengue virus-2 in Kenya. Viral RNA from acutely ill patients in Kenya was enriched and sequenced. Six new dengue-2 genomes were combined with 349 publicly available genomes and phylogenies used to infer gene flow between Kenya and other...
Topics
- Dengue Virus
- Dengue
- Humans
- Phylogeny
- Kenya
- Evolution, Molecular
- Phylogeography
- Molecular Epidemiology
- Africa, Eastern