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Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes.

Nature communications - 5 Sept 2024

Ravikrishnan Aarthi, Wijaya Indrik, Png Eileen, Chng Kern Rei, Ho Eliza Xin Pei, Ng Amanda Hui Qi, Mohamed Naim Ahmad Nazri, Gounot Jean-Sebastien, Guan Shou Ping, Hanqing Jasinda Lee, Guan Lihuan, Li Chenhao, Koh Jia Yu, de Sessions Paola Florez, Koh Woon-Puay, Feng Lei, Ng Tze Pin, Larbi Anis, Maier Andrea B, Kennedy Brian K, Nagarajan Niranjan

Abstract excerpt

While rapid demographic changes in Asia are driving the incidence of chronic aging-related diseases, the limited availability of high-quality in vivo data hampers our ability to understand complex multi-factorial contributions, including gut microbial, to healthy aging. Leveraging a well-phenotyped cohort of community-living octogenarians in Singapore, we used deep shotgun-metagenomic sequencing for...

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PMID: 39237540
DOI: 10.1038/s41467-024-52097-9
PMCID: PMC11377447

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