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Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs.

Biology of sex differences - 2 Sept 2024

Wu Jinhua, Tan Shuwen, Feng Zheng, Zhao Haiquan, Yu Congying, Yang Yin, Zhong Bingzhou, Zheng Wenxiao, Yu Hui, Li Hua

Abstract excerpt

BACKGROUND: Differences of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. In more than 50% of human DSD cases, a molecular diagnosis is not available. In intensively farmed pig populations, the incidence of XX DSD pigs is relatively high, leading to economic losses for pig breeders. Interestingly, in the majority of 38, XX DSD pigs, gonads still...

Topics

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Disorders of Sex Development
SRY gene
WWOX gene
Polymorphism, Single Nucleotide
Sexual Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39223676
DOI: 10.1186/s13293-024-00644-w
PMCID: PMC11367908

Genes

IFITM1
NOBOX
SRY
WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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