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Article

A dominant-negative Arabidopsis cation exchanger 1 (CAX1): N-terminal autoinhibition and membrane topology.

The Plant journal : for cell and molecular biology - 1 Sept 2024

Sarkar Shayan, Rhein Hormat Shadgou, Pittman Jon K, Hirschi Kendal D

Abstract excerpt

Calcium (Ca2+) is essential for plant growth and cellular homeostasis, with cation exchangers (CAXs) regulating Ca2+ transport into plant vacuoles. In Arabidopsis, multiple CAXs feature a common structural arrangement, comprising an N-terminal autoinhibitory domain followed by two pseudosymmetrical modules. Mutations in CAX1 enhance stress tolerance, notably tolerance to anoxia (a condition marked by oxygen...

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PMID: 39175446
DOI: 10.1111/tpj.16966

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